June 2006

Welcome to the Second Issue of Retina Today

We hope you enjoyed the first issue of Retina Today and are ready to dive into the second edition.

New Molecular Targets in the Treatment of Ocular Neovascular Diseases

The role of platelet-derived growth factor-B for inhibiting growth of aberrant vessels.

David T. Shima, PhD, and Anthony P. Adamis, MD

Intravitreal Bevacizumab for the Treatment of Subfoveal CNV Secondary to AMD

Data continue to support further evaluation of intravitreal bevacizumab with large controlled prospective trials.

Caroline R. Baumal, MD, and David Eichenbaum, MD

Angiographic Interpretation of Neovascular AMD by Different ‘Reading Centers'

This analysis suggests that VEGF is a common denominator in neovascular AMD, regardless of subtype classification.

Michael S. Ip, MD

Subthreshold Laser Not Protective in Eyes With Drusen

Results from the PTAMD study showed a modest treatment benefit, particularly in eyes with pretreatment visual acuity between 20/32 and 20/63.

Conni Bergmann Koury, Editor-in-Chief

Monotherapy vs Combination Therapy for Wet AMD: Is Ranibizumab the Insulin of AMD?

This article was presented in part as a talk during the Retina Controversies Section of the Canadian Ophthalmology Society meeting, Toronto, Ontario June 23, 2006.

David M. Brown, MD, and Tom Sheidow, MD, FRCS(C)

Ruboxistaurin: Useful in Preventing Visual Loss in Diabetic Patients

Patients treated with the PKC-beta inhibitor had less visual acuity loss over a 3-year period versus those treated with placebo.

Laura Suarez, Managing Editor

Rosiglitazone May Delay Progression to PDR

Previous in vitro and animal studies have identified antiangiogenic activity of this agent.

CONNI BERGMANN KOURY, EDITOR-IN-CHIEF

Pegaptanib May Improve Diabetic Retinopathy

The phase 3 clinical trial will focus on longer treatment duration to further test the drug's efficacy.

Laura Suarez, Managing Editor

Quantification and Volumetric Imaging of Retinal Pathologies Using High-Speed Ultrahigh Resolution OCT

High-speed UHR-OCT of the retina allows for evaluation of volumetric analysis and thickness mapping of individual retinal layers. In the future, this may provide retinal specialists with a unique diagnostic tool in the management of retinal pathologies.

Conni Bergmann Koury, Editor-in-Chief

Miniaturized Instruments in Vitreoretinal Surgery: The Future?

The time advantage gained by the use of the sutureless technique could imaginably be lost by the need for a longer vitrectomy time.

Barbara Wimpissinger, MD; Lukas Kellner, MD; Ulrike Stolba, MD; and Susanne Binder, MD

Results of the SPR Study: Scleral Buckling vs Primary Vitrectomy in Retinal Detachment

In patients with rhegmatogenous retinal detachment, the most appropriate operating method is often controversial, with surgeons using different techniques.

Conni Bergmann Koury, Editor-in-Chief

Autologous Transplantation of RPE for the Management of Acute Exudative AMD

Robert E. MacLaren, FRCOphth, FRCS, DPhil

Clinical Trial Update: Retinal Surgery

Trial: Full Thickness Macular Hole (FTMH) and Internal Limiting Membrane (ILM) Peeling Study

Molecular Biology of Diabetic Retinopathy: How to Best Preseve Vision in these Patients

Jointly sponsored by The Dulaney Foundation and Retina Today. Release Date: July 2006. Expiration Date: July 31, 2007. This continuing medical education activity is supported by an educational grant from Eli Lilly and Company.

Lloyd Paul Aiello, MD, PhD

2006 ARVO Annual Award Winners