Advanced imaging with spectral-domain optical coherence tomography (SD-OCT) enables clinicians to detect details of chorioretinal pathology like never before. Small, subtle changes in the macula and even in the retinal periphery can now be seen, allowing for more targeted treatment and better outcomes, both medically and surgically. The SPECTRALIS system (Heidelberg Engineering, Heidelberg, Germany) provides OCT images in fine detail and confocal, blue laser autofluorescence (BluePeak) fundus images which are highly sensitive in picking up areas of RPE and retinal abnormalities. In this supplement to Retina Today, the assembled faculty present cases where the SPECTRALIS proved essential in detecting different, and at times challenging, pathology. This series of cases includes sideby- side comparisons with standard imaging methods and our panel of experts provide some interesting pearls for interpreting the data that are produced by SD-OCT imaging.